Podcast Interview with Dr. Fran Kendall on Mitochondria Disease

Karen Thomas interviews Dr. Fran Kendall, M.D.

Dr. Kendall-mitochondria

Dr. Kendall is a Harvard trained physician with a career of over 30 years specializing in metabolic, mitochondrial, and inherited (genetic) disorders. This interview focuses on mitochondrial disease, a lesser known, but common genetic disorder causing symptoms ranging from seizures, GI problems, fatigue, and Rett Syndrome. Dr. Kendall is an expert in this field. In this interview we discuss what you need to know about mitochondrial disease and what you can do about it.

Fifty percent of all children with autism have mitochondrial disease and most are never diagnosed.

Please listen to this very informative interview.

Mitochondria give cells over 90% of their energy. Without proper energy cells cannot carry out their functions.

Mitochondrial Dysfunction vs Mitochondrial Disease

Mitochondrial dysfunction simply means that the mitochondria are not working correctly. Mitochondrial disease is the term used when the primary cause of mitochondrial dysfunction resides in the mitochondria. Mitochondrial disease is generally genetic. It can be inherited from either or both parents. A special type of mitochondrial disease is caused by mutations on the mitochondrial DNA, and is inherited only from the mother. When the primary cause of mitochondrial dysfunction resides outside the mitochondria, mitochondrial dysfunction is called “secondary” (to something else).

Symptoms of Mitochondrial Dysfunction

Cellular energy is necessary for the function of all cells, but is particularly critical for nerve and muscle. Both nerve and muscle are important in GI function, thus cyclic vomiting, constipation, diarrhea, poor GI mobility, and other digestive disorders are common. Additional potential complications of mitochondrial dysfunction include chronic fatigue, neuropathic pain, depression, autistic regression, seizures, hypoglycemia, visual and hearing difficulty, depression, anxiety, panic disorder, intellectual disability, and dysautonomia.

Mitochondrial Triggers

Mitochondrial dysfunction can be genetic, but even then, disease is often triggered by the environment. Viral infections are among the most common triggers of mitochondrial dysfunction. Additional potential triggers are other infections (e.g. lyme bacteria), vaccinations, toxins, anesthesia, and any other significant stressor. In order situations, mitochondrial dysfunction can be acquired. In fact, stroke and heart attack involve mitochondrial dysfunction, whereas cells are receiving insufficient oxygen for required energy metabolism. Many environmental toxins can poison mitochondria as well, including some pesticides.

Treating Mitochondrial Dysfunction

The good news is that mitochondrial dysfunction in general can be treated. In Dr. Richard  Boles’ experience, about 80% of people with mitochondrial dysfunction improve on proper treatment, including people with autism. Of course, this requires a broad-based treatment approach with strong foundational aspects including good diet, supplements, exercise, adequate sleep, avoidance of environmental triggers, and more. Of particular importance is the combination and dosages of specific supplements including the bioavailable form of coenzyme Q10 (ubiquinol), L-carnitine, riboflavin (vitamin B2), vitamin C, alpha lipoic acid, vitamin D, and others.

Related resources:


SpectrumNeeds mitochondrial supplement (powder form)

Ubiquinol from SpectrumNeeds (soft gel capsules)

Study by Richard Frye on autism and mitochondria

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